Here in Silicon Valley, I have taken part in hundr...

Science and vision are not opposites or even at odds. They need each other. I sometimes hear other startup folks say something along the lines of: 'If entrepreneurship was a science, then anyone could do it.' I'd like to point out that even science is a science, and still very few people can do it, let alone do it well.

The attributes for entrepreneurs cut both ways. You need the ability to ignore inconvenient facts and see the world as it should be and not as it is. This inspires people to take huge leaps of faith. But this blindness to facts can be a liability, too. The characteristics that help entrepreneurs succeed can also lead to their failure.

I can't say I'm not grateful to have journalists writing about me as a genius. But I know it's not true. I'm not confused. I understand that success comes through a lot of failure and a lot of very embarrassing failure. People want to create the next Facebook, but they are too afraid to create the next Facemash.

After you're older, two things are possibly more important than any others: health and money.

You end up as you deserve. In old age you must put up with the face, the friends, the health, and the children you have earned.

Talk is by far the most accessible of pleasures. It costs nothing in money, it is all profit, it completes our education, founds and fosters our friendships, and can be enjoyed at any age and in almost any state of health.

My age and health will never allow me to realize the dream of art I've been pursuing all my life.

Liberal that I am, I support health-care reform on its merits alone. My liberal blood boils, for example, when I read that half of the personal bankruptcies in this country are brought on, in part, by medical expenses.

There is an element of anger among women who've been raped. There's certainly a major element of humiliation. But it really does seem like a medical condition of shock and horror.

The best doctor is the one you run to and can't find.

Time is generally the best doctor.